Measurement of a Dendritic MS Reference Standard [MALDI Application]

A high-quality mass calibration is required to achieve highly accurate mass measurements by mass spectrometry.A polymer or a mixture of peptides is commonly used to calibrate a MALDI-TOF MS system. However, peptides do not necessarily have long-term stability, and a monodisperse polymer does not have a wide m/z range. Sometimes these standards are not well suited for calibration over a wide m/z range. We used a new dendritic MS calibrant (SpheriCal®) to resolve these issues. Here we demonstrate measurement and calibration using the new calibrant with the JEOL SpiralTOF MALDI mass spectrometer.

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