Identifying crystal polymorphs of a drug compound by solid state NMR
Shown below are 13C NMR spectra of 3 types of indomethacin that are different in crystal structure. While liquid NMR data show no difference, solid NMR spectrometry, which analyzed the sample in powder form, identified each crystal polymorph.
Instrument: JNM-ECZ500R; probe: liquid ROYAL, solid 3.2 mm XH MAS
Sample courtesy of Prof. Kenjiro Higashi, Chiba University