No-D NMR is a method to measure NMR spectra of organic compounds without deuterated solvents. JEOL’s latest NMR software, Delta NMR software Ver.5, includes automation sequences for No-D NMR, as standard. The sequences can be used more easily than the previous ones, more solvents can be selected, and so more promising.
Advantages of No-D
- Time for preparing samples can greatly be reduced, because reaction solutions can be used as they are.
- Unstable samples can be measured, because the process of dissolving samples is omitted.
- The cost for deuterated solvents can be saved.
Simlified setting parameters and selecting solvents
When an automation sequence is selected, only the parameters often changed are displayed as method parameters, providing efficient setting.
A measuremtent can immediately be started, when
- wet_solvent: name of solvent
- peaks: number of solvent peaks
are set. As standard, 22 normal solvents can be selected, and more solvents can be added on request.
* The othe parameters are in the subdirectory.
Automatic detection of solvent peaks and adjustment of reference
No-D automation sequence starts with a 1-scan H measurement to search a solvent signal (scout scan). Then, WET measurement is performed to suppress the solvent signal and also set reference using the signal. Hence, users can save the step of setting reference.
No-D NMR when a solvent gives more than one peak
WET sequence has an advantage of suppressing more than one solvent peak at once, and so No-D NMR is applicable to such solvents. In the example of methanol, two peaks are suppressed by setting peaks to be 2.
No-D NMR when more than one solvent are used
No-D NMR is applicable to the case when more than one solvents are used. In the example shown below, solvent signals from water and acetone are suppressed.
List of selectable solvents
Acetic acid, acetone, acetonitrile, benzene, chloroform, cyclohexane, DMF, DMSO, ethanol, hexafluoro-2-propanol, isopropanol, methanol, methylene chloride, nitromethane, o-dichlorobenzene, p-dioxane, pyridine, tetrachloroethane, tetrahydrofuran, toluene, trifluoroacetic acid, trifluoroethanol
* More solvents can be added on request. However, note that adjacent peaks may accidentally suppressed if many solvents are specified.