CRAFT (Complete Reduction to Amplitude Frequency Table)

  • Summary


CRAFT(Complete Reduction to Amplitude Frequency Table)

CRAFT is able to transform NMR data from the FID (Free Induction Decay, time domain data) to a table consisted of frequency and amplitude for each frequency component (see right figure). This process is automatically performed by the Bayesian approach.

It is a good solution for analyzing cloudy spectra with overlapped signals where accurate integration is usually difficult to perform. It will also accurately quantify the signal strength against solvent suppressed data even if it has baseline distortions.

Furthermore, CRAFT is suited to high-throughput analysis as it is able to analyze many sets of data simultaneously.

*CRAFT (complete reduction to amplitude frequency table) – robust and time-efficient Bayesian approach for quantitative mixture analysis by NMR, Krish Krishnamurthy, Magn. Reson. Chem., 51, p 821-829, (2013)

Application fields

qNMR (quantitative NMR), Metabolomics, Other applications which require integration process.

CRAFT analysis of 1H-NMR for brucine

CRAFT model data (green) which is reconstructed from each component of the amplitude frequency table is almost identical to  (brown) original data (blue).

Solvent-free sample preparation.
Please see the PDF file for the additional information.
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