JMS-S3000 SpiralTOF™ series Life Science Applications Notebook

This is a compendium of life science related applications notes, JEOL News articles, and scientific journal articles based on the data acquired on JEOL ultra-high mass-resolution MALDI-TOFMS JMS-S3000 SpiralTOF™ series.

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Table of Contents

Introduction and Fundamentals　P1〜

• Development of JMS-S3000: MALDI-TOF/TOF Utilizing a Spiral Ion Trajectory (Takaya Satoh, JEOL News, 45, 34-37, 2010)

• The Relationship between Crystal Condition and Mass Resolving Power, Mass Accuracy (MSTips No. 206)

Proteins and Peptides　P11〜

• High-Resolution Measurements of Proteins Using the Spiral Mode of JMS-S3000 "SpiralTOF™" (MSTips No. 297)

• MALDI-ISD Measurements Using Both the SpiralTOF™ Mode and the Linear Mode (MSTips No. 229)

• High Resolution and High Mass Accuracy MALDI-ISD Measurements (MSTips No. 228)

• High Sensitivity Analysis of Intact Proteins Using Linear TOF (MSTips No. 227)

• High Sensitivity Peptide Measurement with the New Matrix α-Cyano-4-Chlorocinnamic Acid

• Distinguishing Lysine and Glutamine in a Peptide

• Analysis of Phosphopeptide Using TOF-TOF (MSTips No. 184)

• Comparison of the JMS-S3000 SpiralTOF™-TOF and a 4-Sector Tandem Double-Focusing Mass Spectrometer (MSTips No. 181)

• Structural Analysis of a High Molecular Weight Peptide (MSTips No. 175)

• High-Energy CID Analysis of Bovine Serum Albumin (MSTips No. 174)

• Analysis of Bovine Serum Albumin (MSTips No. 166)

Lipids　P39〜

• Structural Analysis of Oxidized Triolein (MSTips No. 197)

• Structural analysis of phospholipids in egg yolk using JMS-S3000 "SpiralTOF™" with TOF-TOF option (MSTips No. 185)

• Structural Analysis of Triolein (MSTips No. 182)

• Structural Analysis of Tristearin (MSTips No. 178)

• Aglycon diversity of brain sterylglucosides: structure determination of cholesteryl- and sitosterylglucoside (Akiyama, H., et al., J. Lipid Res. 57, 2061–2072, 2016; open access article under the CC BY license)

• Structural Analysis of Triacylglycerols by Using a MALDI-TOF/TOF System with Monoisotopic Precursor Selection (Kubo, A., et al., J. Am. Soc. Mass Spectrom., 24, 684–689, 2013; open access article ©The Authors, 2012)

Nucleic Acids / Natural Products / Oligosaccharides　P65〜

• Analysis of oligonucleotides using JMS-S3000 "SpiralTOF™-plus 2.0" (MSTips No. 364)

• Analysis of the Natural Organic Compound SAAF by Using the TOF-TOF Option (MSTips No. 183)

• Analysis of the Natural Organic Compound YTX by Using the TOF-TOF Option

• High-energy CID Mass Spectrometry of Oligosaccharides (MSTips No. 366)

Drugs / Small Molecules　P75〜

• Structural analysis of a small molecule using JMS-S3000 "SpiralTOF™-plus 2.0" ー MS/MS measurement of a photodegradation product of reserpine ー (MSTips No. 365)

• Analysis of a drug in urine by JMS-S3000 "SpiralTOF™" and TOF-TOF option (MSTips No. 263)

• Structural analysis of melatonin and related compounds using JMS-S3000 SpiralTOF™ with the TOF-TOF option (MSTips No. 256)

• Analysis of medicinal properties in a combination cold remedy by using JMS-S3000 "SpiralTOF™" (MSTips No. 241)

• High-Energy CID MS-MS Analysis of Small Organic Molecules (MSTips No. 173)

• MALDI for Small Molecule Analysis: A Complex Drug Mixture

• Accurate mass measurement of small organic molecules using JMS-S3000 "SpiralTOF™" (MSTips No. 168)

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